33 published clinical trials done with cannabis in the US. List compiled by Dr. Sunil Aggarwal in 2009 showing efficacy for anti-nausea, anti-emesis, spasticity, appetite, neuropathic pain, intraocular hypertension (glaucoma), weight gain.

1. Ellis RJ, Toperoff W, Vaida F, et al.: Smoked medicinal cannabis for neuropathic pain in HIV: A randomized, crossover clinical trial. Neuropsychopharmacology. 2009; 34(3): 672-680.

2. Wilsey B, Marcotte T, Tsodikov A, et al.: A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic pain. J Pain. 2008; 9: 506-521.

3. Corey-Bloom J, Wolfson T, Gamst A, et al.: Short-term effects of medicinal cannabis on spasticity in multiple sclerosis.60th Annual Meeting of the American Academy of Neurology, Chicago, IL, 2008. Available at www.cmcr.ucsd.edu/geninfo/jcb_aan_poster.pdf. Accessed April 28, 2009.

4. Abrams DI, Jay CA, Shade SB, et al.: Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo controlled trial. Neurology. 2007; 68: 515-521.

5. Abrams DI, Vizoso HP, Shade SB, et al.: Vaporization as a smokeless cannabis delivery system: A pilot study. Clin

Pharmacol Ther. 2007; 82: 572-578.

6. Haney M, Gunderson EW, Rabkin J, et al.: Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep. J Acquir Immune Defic Syndr. 2007; 45: 545-554.

7. Wallace M, Schulteis G, Atkinson JH, et al.: Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers. Anesthesiology. 2007; 107: 785-796.

8. Haney M, Rabkin J, Gunderson E, et al.: Dronabinol and marijuana in HIV(+) marijuana smokers: Acute effects on caloric intake and mood. Psychopharmacology. 2005; 181: 170-178.

9. Abrams DI, Hilton JF, Leiser RJ, et al.: Short-term effects of cannabinoids in patients with HIV-1 infection. A randomized, placebo-controlled clinical trial. Ann Intern Med. 2003; 139: 258-266.

10. Soderpalm AH, Schuster A, de Wit H: Antiemetic efficacy of smoked marijuana: Subjective and behavioral effects on nausea induced by syrup of ipecac. Pharmacol Biochem Behav. 2001; 69: 343-350.

11. Abrams D, Leiser R, Shade S, et al.: Short-term effects of Cannabinoids on HIV-1 viral load. [abstract no. LbPeB7053]. Poster, XIII International AIDS Conference in Durban, South Africa. July 9-14, 2000; 13: 45.

12. Greenwald MK, Stitzer ML: Antinociceptive, subjective and behavioral effects of smoked marijuana in humans. Drug Alcohol Depend. 2000; 59: 261-275.

13. Greenberg HS, Werness SAS, Pugh JE, et al.: Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers. Clin Pharmacol Ther. 1994;55: 324-328.

14. New York Department of Health study, 1990. In Musty RE, Rossi R: Effects of smoked cannabis and oral9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials. J Cannabis Ther. 2001; 1: 29-56.

15. Research Advisory Panel: Cannabis therapeutic research program. Report to the California Legislature, 1989. In Musty RE, Rossi R: Effects of smoked cannabis and oral d9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials. J Cannabis Ther. 2001; 1: 29-56.

16. Foltin RW, Fischman MW, Byrne MF: Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. Appetite. 1988; 11: 1-14.

17. Foltin RW, Brady JV, Fischman MW: Behavioral analysis of marijuana effects on food intake in humans. Pharmacol Biochem Behav. 1986; 25: 577-582.

18. Behavioral Health Sciences Division: The Lynn Pierson therapeutic research program. Health and Environment Department: New Mexico, 1984. In Musty RE, Rossi R: Effects of smoked cannabis and oral d9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials. J Cannabis Ther. 2001; 1: 29-56.

19. Behavioral Health Sciences Division: The Lynn Pierson therapeutic research program. Health and Environment Department: New Mexico, 1983. In Musty RE, Rossi R: Effects of smoked cannabis and oral d9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials. J Cannabis Ther. 2001; 1: 29-56.

20. Board of Pharmacy, State of Tennessee: Annual report: Evaluation of marijuana and tetrahydrocannabinol in the treatment of nausea and/or vomiting associated with cancer therapy unresponsive to conventional anti-emetic therapy: Efficacy and toxicity, 1983. In Musty RE, Rossi R: Effects of smoked cannabis and oral d9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials. J Cannabis Ther. 2001; 1: 29-56.

21. Kutner MH: Evaluation of the use of both marijuana and THC in cancer patients for the relief of nausea and vomiting associated with cancer chemotherapy after failure of conventional anti-emetic therapy: Efficacy and toxicity, as prepared for the Composite State Board of Medical Examiners, Georgia Department of Health, by physicians and researchers at Emory University, Atlanta, 1983. In Musty RE, Rossi R: Effects of smoked cannabis and oral d9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials. J Cannabis Ther. 2001; 1: 29-56.

22. Department of Social Oncology, Evaluation Unit, State of Michigan: Marihuana therapeutic research project, 1982. In Musty RE, Rossi R: Effects of smoked cannabis and oral d9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials. J Cannabis Ther 2001; 1: 29-56.

23. Chang AE, Shiling DJ, Stillman RC, et al.: A prospective evaluation of delta-9 tetrahydrocannabinol as an antiemetic in patients receiving adriamycin and cytoxan chemotherapy. Cancer. 1981; 47: 1746-1751.

24. Merritt JC, Crawford WJ, Alexander PC, et al.: Effect of marihuana on intraocular and blood pressure in glaucoma. Ophtalmology. 1980; 87: 222-228.

25. Chang AE, Shiling DJ, Stillman RC, et al.: Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high dose methotrexate. Ann Inten Med. 1979; 91: 819-824.

26. Crawford WJ, Merritt JC. Effects of tetrahydrocannabinol on arterial and intraocular hypertension. Int J Clin Pharmacol Biopharm. 1979; 17: 191-196.

27. Greenberg I, Kuehnle J, Mendelson JH, et al.: Effects of marijuana use on body weight and caloric intake in humans. Psychopharmacology. 1976; 49: 79-84.

28. Tashkin DP, Shapiro BJ, Frank IM: Acute pulmonary physiologic effects of smoked marijuana and oral A9-tetrahydrocannabinol in healthy young men. N Engl J Med. 1973; 289: 336-341.

29. Hill SY, Schwin R, Goodwin DW, et al.: Marihuana and pain. J Pharmacol Exp Ther. 1974; 188: 415-418.

30. Tashkin DP, Shapiro BJ, Frank IM: Acute effects of smoked marijuana and oral d9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects. Am Rev Respir Dis. 1974;109: 420-428.

31. Tashkin DP, Shapiro BJ, Lee YE, et al.: Effects of smoked marijuana in experimentally induced asthma. Am Rev Respir Dis. 1975; 112: 377-386.

32. Vachon L, Fitzgerald MX, Solliday NH, et al.: Single-dose effect of marihuana smoke: Bronchial dynamics and respiratory-center sensitivity in normal subjects. N Engl J Med. 1973; 288: 985-989.

33. Hollister LE: Hunger and appetite after single doses of marihuana, alcohol, and dextroamphetamine. Clin Pharmacol Ther. 1971; 12: 44-49.